Carpenter-Shen Lab | Purdue University

CellsCures

Very few people get to solve puzzles all day long
and directly help patients suffering from disease.

What We Do

Research

At the Carpenter-Shen Lab at Purdue University, we develop advanced methods and software to make discoveries in cell images. The rich information can reveal the causes and cures for diseases, and the impact of chemicals on biological systems. We work across all disease areas, from cancer and psychiatric disease to rare disorders and infectious disease.

Anne Carpenter: When Biology Meets Computer Science

Runxi Shen: Cell Painting for Rare Disease and Drug Discovery

Our Focus

Problems to solve

Variant Integration for Screening Therapeutic Approaches (VISTA)

Rescuing Mislocalized Proteins

When a critical protein ends up in the wrong place inside a cell, disease can follow. We systematically screen thousands of approved drugs to find ones that guide these proteins back to where they belong, turning medicines we already have into new cures.

VISTA Consortium

Omics for Assessing Signatures for Integrated Safety (OASIS)

Predicting Chemical Safety

We combine cellular imaging, transcriptomics, and proteomics across a global network of scientists to build predictive tools for chemical safety, reducing reliance on animal testing and bringing safer medicines to people faster.

OASIS Consortium

Joint Undertaking in Morphological Profiling (JUMP)

Mapping the Chemical Universe

We are building the world’s largest open library of how cells respond to over 136,000 drugs and genetic changes, giving AI the training data it needs to accelerate the discovery of new medicines for any disease.

JUMP Consortium